Sir Percivall Pott and his Cancer Research

Sir Percivall Pott

Sir Percivall Pott

On January 6, 1714, English surgeon Sir Percivall Pott was born. Pott is considered one of the founders of orthopedy, and the first scientist to demonstrate that a cancer may be caused by an environmental carcinogen.

Percivall Pott was raised by his mother and Joseph Wilcocks, the bishop of Rochester, since his father died when he was still young. Pott attended a private school in Kent and later was an apprentice to an assistant surgeon to St Bartholomew‘s Hospital, Edward Nourse. There, Pott prepared and dissected cadavers for Nourse’s anatomy classesa and not only became educated in the basic principles of anatomy and medicine but also eventually perfected his surgical technique.
In 1736, Pott himself was admitted to the BarbersCompany and was licensed to practise. Pott became assistant surgeon to St Bartholomew‘s in 1744 and full surgeon from 1749 till 1787.

In 1956, Percivall Pott fell from a horse and broke his lower leg. He proceded to instruct his helpers to build a makeshift stretcher from a door and poles, which was then used to carry him home. Even though the recommended standard procedure back then was to amputate the leg, Nourse suggested to apply traction and pressure to the fracture to correct the positioning of the bones. Nourse’s technique worked, and Pott’s leg healed without complication. The approach was later further refined resulted in a substantial decline in amputations. Also, fractures of the lower leg similar to the type Pott suffered became known as Pott fracture.

In 1775, Pott found an association between exposure to soot and a high incidence of scrotal cancer (later found to be a type of squamous cell carcinoma) in chimney sweeps. This unusual disease, later termed chimney sweeps’ carcinoma due to Pott‘s investigation, was the first occupational link to cancer, and Pott became the first person to associate a malignancy with an environmental carcinogen. Pott implicated chimney soot as a direct contact carcinogen to skin. In 1933, experiments with animals showed that painting coal tar onto skin would demonstrate the role of the first proven chemical carcinogen benzo(a)pyrene, which occurs in high concentrations in smoke and chimney soot, with the process that Pott first identified. Percivall Pott‘s investigations significantly contributed to the science of epidemiology and the Chimney Sweepers Act 1788, which was passed to try to stop child labour since many boys as young as four were being used as chimney sweeps. Percivall Pott described the sweepscarcinoma:

It is a disease which always makes it first attack on the inferior part of the scrotum where it produces a superficial, painful ragged ill-looking sore with hard rising edges…..in no great length of time it pervades the skin, dartos and the membranes of the scrotum, and seizes the testicle, which it inlarges(sic), hardens and renders truly and thoroughly distempered. Whence it makes its way up the spermatic process into the abdomen

As part of the treatment, the diseased flesh was cut out or alternatively there was the application of an arsenic paste poultice. However, the cause of this cancer was unproved until the discovery of weak carcinogens in soot by Passley in 1922. Until then the most popular theory was that soot got trapped in the rugae of the scrotum and this caused a general irritation. Sweeps were not known for their attention to bodily hygiene and it was assumed they never washed their genitals. The youngest known victim, recorded in 1790 by James Earle (Pott’s son-in-law), was only 8 years old.

In 1765, Percivall Pott was elected Master of the Company of Surgeons, the forerunner of the Royal College of Surgeons of England.

References and Further Reading:

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